In the Harrington lab, we are focused on investigating the impact of circadian time on health and disease by utilizing both in vivo and in vitro models.
To better understand the progression of Alzheimer’s Disease (AD) and to identify potential therapeutic targets, our lab investigates the interactions between circadian rhythm disruption, vascular insufficiency, and AD-associated pathology.
To better understand the health impact of circadian disruption on health, we are also researching the ability of peripheral organs, such as the liver, to maintain time and sync with the environment even when the central clock in the suprachiasmatic nucleus is ablated.