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Dave Gorin

Assistant Professor of Chemistry
Smith College

Office: Ford Hall 310
Phone: (413)-585-3889
Fax: (413)-585-3786
Email: dgorin(at)smith.edu

EDUCATION

Ph.D., University of California, Berkeley, Dept. of Chemistry
Advisor, F. Dean Toste

A.B., cum laude in chemistry, Harvard University

PROFESSIONAL HISTORY

Smith College, 2011-present 
Assistant Professor of Chemistry

Harvard University, 2008-2011
Dept. of Chemistry and Chemical Biology
American Cancer Society-Canary Foundation Postdoctoral Fellow
Advisor, David R. Liu

RESEARCH INTERESTS

Organic and bioorganic chemistry. Exquisitely selective chemical catalysts and reagents are needed for the modification and functional perturbation of molecules in complex contexts, such as in biological and environmental samples. Since chemists have traditionally been concerned with the transformation of a single, pure starting material into a product, few reagents are capable of selectively functionalizing one compound in a mixture, especially if similar functional groups are present among the starting compounds. My lab will use tools from synthetic chemistry and molecular biology to develop new classes of catalysts that selectively functionalize one component of a mixture and discriminate among multiple instances of a functional group.  

PUBLICATIONS

"Catalytic Methyl Transfer from Dimethylcarbonate to Carboxylic Acids," Ji, Y.*; Sweeney, J.*; Zoglio, J.*; Gorin, D. J. Journal of Organic Chemistry 2013, 78, 11606-11611.

"Interaction-Dependent PCR Identifies Target-Ligand Pairs from Libraries of Targets and Ligands" McGregor, L. M.; Gorin, D. J.; Dumelin, C. E.; Liu, D. R. Journal of the American Chemical Society 2010, 132, 15522-15524.

"Reactivity-Dependent PCR: Direct, Solution-Phase in Vitro Selection for Bond Formation" Gorin, D. J.; Kamlet, A. S.; Liu, D. R. Journal of the American Chemical Society 2009, 131, 9189-9191.

"Ligand Effects in Homogeneous Gold Catalysis" Gorin, D. J.; Sherry, B. D.; Toste, F.D. Chemical Reviews 2008, 108, 3351-3378.

"Fluorenes and Styrenes by Au(I)-Catalyzed Annulation of Enynes and Alkynes " Gorin, D. J.; Watson, I. D. G.; Toste, F. D. Journal of the American Chemical Society 2008, 130, 3736-3737.

"Triphenylphosphinegold(I) chloride" Gorin, D. J.; Sherry, B. D.; Toste, F. D. Encyclopedia of Reagents for Organic Synthesis 2008.

"Relativistic Effects in Homogeneous Gold Catalysis" Gorin, D. J.; Toste, F. D. Nature 2007, 446, 395-403.

"Synthesis of Benzonorcaradienes via Gold(I)-Catalyzed [4+3] Annulation" Gorin, D. J.; Dube, P.; Toste, F. D. Journal of the American Chemical Society 2006, 128, 14480-14481.

"Gold(I)-Catalyzed Stereoselective Olefin Cyclopropanation." Johansson, M. J.; Gorin, D. J., Staben, S. T.; Toste, F. D. Journal of the American Chemical Society 2005, 127, 18002-18003.

"Gold(I)-Catalyzed Intramolecular Acetylenic Schmidt Reaction." Gorin, D. J.; Davis, N. R.; Toste, F. D. Journal of the American Chemical Society 2005, 127, 11260-11261.

"Synthesis of 2-Cyclopentenones by Gold(I)-Catalyzed Rautenstrauch Rearrangement." Shi, X.; Gorin, D. J.; Toste, F. D. Journal of the American Chemical Society 2005, 127, 5802-5803.

"Discovery of a novel class of benzazepinone Nav 1.7 blockers: potential treatments for neuropathic pain" Hoyt, S. B.; London, C.; Gorin, D.; Wyvratt, M. J.; Fisher, M. H.; Abbadie, C.; Felix, J. P.; Garcia, M. L.; Li, X.; Lyons, K. A.; McGowan, E.; MacIntyre, D. E.; Martin, W. J.; Priest, B. T.; Ritter, A.; Smith, M. M.; Warren, V. A.; Williams, B. S.; Kaczorowski, G. J.; Parsons, W. H. Bioorganic and Medicinal Chemistry Letters 2007, 17, 4630-4634.

* denotes Smith undergraduate co-author


Last modified on February 20 2014 08:40:54.