FROM THE DIRECTOR

The Edna McConnell Clark Foundation
250 Park Avenue, New York, NY 10177-0026
Tel: (212)986-7050 Fax: (212)986-4558

June, 1992

Dear Oncho Investigator,

Since our meeting at Woods Hole in April of 1991, things have moved along briskly for the EMCF-sponsored onchocerciasis research. The mouse chamber model of David Abraham has been confirmed in its ability to detect immunity by Simon Townson, Mark Taylor, and Ted Bianco. The Clark Foundation has set up a vaccine screening program involving Richard Lucius in Heidelberg and David Abraham in Philadelphia. Additionally, the Foundation Trustees approved support for Rocky Tuan to carry out in situ hybridization and immunohistology for localization of antigens in oncho parasites.

All of this has led to the need to communicate more directly with laboratories working on the immunology and vaccine development for onchocerciasis. This is the first in a series of informal newsletters, "The Greene Sheet:, that will be prepared by the Oncho Task Force to keep you abreast of activities and progress in our onchocerciasis research program. It is intended to begin an exchange of information, so your response to this newsletter, with news and comments--and even complaints--to Cathy Steel, the editor, will be helpful to your colleagues. Subsequent issues will provide space for this exchange as well as news prepared by the Oncho Task Force.

I hope you will find this newsletter useful and that it will contribute to the continuing fast pace of research on onchocerciasis.

With best wishes,

Yours sincerely,

Joseph A. Cook, M.D., Director
Program in Tropical Disease Research