Acetyltransferase

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Acetyltransferase

Aminoglycoside acetyltransferase is an acetyltransferase that confers resistance to aminoglycoside antibiotics by catalyzing a reaction that modifies the aminoglycoside. During the reaction, an acetyl group is added to an amino group on the aminoglycoside. This reaction is dependent on the presence of an acetyl-CoA group. This renders the antibiotic ineffective so it no longer binds to the ribosomal unit during translation. Protein synthesis is thereby allowed to procede in the bacterium. [1].

References

  1. (1997) Davies J and Wright G. 1997. Bacterial Resistance to Aminoglycoside Antibiotics. Trends in Microbiology 5:234-39